Avelox Injection (Moxifloxacin 400mg/250mL) – Broad-Spectrum IV Antibiotic for Severe Bacterial Infections
Avelox Injection (Moxifloxacin 400mg) – IV Antibiotic for Respiratory, Skin, and Abdominal Infections | Buy Online from EZ Chemist Pharmacy
What is Avelox Injection used for?
Avelox Injection, containing moxifloxacin, is a broad-spectrum fluoroquinolone antibiotic used to treat serious bacterial infections such as community-acquired pneumonia, intra-abdominal infections, and skin infections. It is administered intravenously when oral antibiotics are not suitable.
Brand Name: Avelox

Generic Name: Moxifloxacin Hydrochloride

Dosage Form: Intravenous infusion solution

Strength: 400 mg/250 mL (1.6 mg/mL)

Drug Class: Fluoroquinolone Antibiotic

Route of Administration: Intravenous (IV)

Prescription Status: Prescription-only (Rx, Schedule H in India)

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Moxifloxacin hydrochloride equivalent to 400 mg moxifloxacin base per 250 mL IV solution
Moxifloxacin IV

Moxifloxacin infusion

Generic Avelox injection

Fluoroquinolone IV antibiotic
Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for DNA replication, transcription, and repair. This bactericidal action disrupts bacterial DNA function and leads to cell death.

It exhibits high tissue penetration and broad coverage against:

Gram-positive bacteria (e.g., Streptococcus pneumoniae)

Gram-negative bacteria (e.g., Haemophilus influenzae)

Anaerobes and atypical pathogens (e.g., Mycoplasma, Legionella, Chlamydia)
Avelox IV is used to treat the following moderate to severe infections in adults:

Community-Acquired Pneumonia (CAP)

Complicated Skin and Skin Structure Infections

Complicated Intra-Abdominal Infections (cIAIs)

Acute Exacerbation of Chronic Bronchitis (if oral route is not feasible)

It is not indicated for pediatric patients or viral infections.
Indication Dose Duration
Community-acquired pneumonia 400 mg IV daily 7–14 days
Complicated intra-abdominal infection 400 mg IV daily 5–14 days
Skin/skin structure infection 400 mg IV daily 7–21 days

Administer by slow IV infusion over 60 minutes

Do not administer via IV bolus
Switch to oral moxifloxacin 400 mg tablets when clinically appropriate
Initiate therapy with IV formulation in patients unable to take oral medication

Evaluate renal and hepatic function before starting

Avoid co-administration with drugs known to prolong QT interval

No dosage adjustment required in renal impairment, but caution is advised
Nausea

Diarrhea

Headache

Injection site reaction

Dizziness

Serious Adverse Events
QT interval prolongation (risk of torsades de pointes)

Tendonitis and tendon rupture

Peripheral neuropathy

Central nervous system effects (seizures, tremor, agitation)

Hypersensitivity or anaphylactic reactions

Clostridium difficile–associated diarrhea
QT Prolongation: Avoid in patients with known QT abnormalities or those taking class IA/III antiarrhythmics

Tendon rupture risk: Especially in elderly and those on corticosteroids

Peripheral Neuropathy: Discontinue immediately if symptoms occur

Hepatotoxicity: Monitor liver function; avoid in severe hepatic dysfunction

CNS Effects: Caution in patients with seizures or psychiatric disorders

Photosensitivity: Avoid prolonged sun exposure
ATC Code: J01MA14

Pharmacologic Class: Fluoroquinolone antibacterial

Schedule: Prescription-Only (Rx, Schedule H)
Interacting Drug/Class Effect / Recommendation
Antiarrhythmics (e.g., amiodarone) ↑ QT prolongation risk
NSAIDs ↑ Risk of CNS stimulation or seizures
Antacids or multivitamins Avoid concurrent use due to reduced absorption
Warfarin Monitor INR; may potentiate anticoagulant effect
Diabetic medications (e.g., insulin) May alter glucose levels
Corticosteroids ↑ Risk of tendon ruptur
Gatifloxacin vs Moxifloxacin Study (CAP, 2005): Moxifloxacin IV demonstrated equal or superior clinical cure rates (87–92%) in hospitalized CAP patients.

AVENTA Trial: Confirmed moxifloxacin IV as non-inferior to standard β-lactam therapy for intra-abdominal infections.

Meta-analysis (Lancet Infectious Diseases, 2016): Moxifloxacin showed excellent tissue penetration and a favorable resistance profile compared to older fluoroquinolones.

FAQs – Frequently Asked Questions
Q1: What is Avelox Injection used for?
Avelox Injection is used for the treatment of serious bacterial infections like pneumonia, skin infections, and abdominal infections when oral therapy is not feasible.

Q2: How is Avelox IV administered?
It is given via slow IV infusion over 60 minutes, once daily.

Q3: Is Avelox Injection safe during pregnancy?
It is classified as Pregnancy Category C. Use only if benefits outweigh risks.

Q4: Can Avelox be used in patients with kidney disease?
No dose adjustment is needed in mild to moderate renal impairment, but monitor closely in severe cases.

Q5: Is moxifloxacin safe in elderly patients?
Use with caution due to QT prolongation and tendon rupture risk.

Q6: Can Avelox be switched to oral tablets?
Yes, once the patient stabilises, switch to Avelox 400 mg oral tablets to complete therapy.

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