Cleocin® Injection (Clindamycin Phosphate) – Potent Lincosamide Antibiotic

Buy Cleocin Injection Online | Clindamycin for Serious Infections

What is Cleocin Injection used for
Cleocin Injection is a prescription clindamycin antibiotic used to treat serious bacterial infections—such as skin, bone, respiratory, and intra-abdominal infections—especially in patients allergic to penicillin. Administered by IV or IM, it inhibits bacterial protein synthesis and is effective against many Gram-positive and anaerobic bacteria.

Brand Name: Cleocin® Injection

Generic Name: Clindamycin Phosphate

Drug Class: Lincosamide Antibiotic

Formulation: Sterile solution for IV/IM injection

Available Strengths: Premixed vials/containers up to 900 mg

Prescription Status: Rx Only (injectable)

Manufacturer: Pfizer (and generics)

Storage: 2–8 °C; protect from light

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Clindamycin Phosphate (equivalent to 300–900 mg clindamycin base)
A semisynthetic lincosamide antibiotic that inhibits bacterial protein synthesis via reversible binding to the 50S ribosomal subunit

Generic Clindamycin

Dalacin C, Clinacin, Clindagel (topical forms)

Clindamycin inhibits the 50S ribosomal subunit, preventing peptide chain initiation and elongation in susceptible bacteria. It is primarily bacteriostatic, with potential bactericidal activity at high concentrations

Cleocin IV/IM is indicated for serious infections caused by susceptible gram-positive cocci and anaerobes when oral therapy or penicillins are inappropriate—including:

Skin/soft tissue (e.g., cellulitis)

Respiratory tract (pneumonia, lung abscess)

Intra-abdominal and pelvic infections

Bone/joint infections (osteomyelitis)

Septicemia

Endocarditis prophylaxis in penicillin-allergic patients
DrugBank

Adults:

Mild to moderate infections: 600–1,200 mg/day IV/IM in 2–4 divided doses

Severe infections (e.g., Bacteroides fragilis): 1,200–2,700 mg/day
RxList

Pediatrics (1 month–16 years):

20–40 mg/kg/day in 3–4 divided doses (up to 450 mg/m²/day)
RxList

Administration:

IM: Give undiluted

IV: Dilute appropriately and infuse slowly (e.g., 10 mg/min for serum levels >4 µg/mL)
DrugBank

Discontinue when patient improves and switch to oral forms

Pregnancy category: Au: A; US: Rx-only

Lactation: Excreted in breast milk; caution advised
NCBI

Geriatric patients: Greater risk of diarrhea and colitis

Renal/hepatic impairment: Use with caution; adjust dose for prolonged therapy

Nausea, vomiting, metallic taste (IV)
Medscape Reference
WebMD
Injection site pain; diarrhea, abdominal discomfort
Medscape Reference

Clostridioides difficile–associated diarrhea (CDAD) – carries a black box warning
Medscape Reference

Hypersensitivity reactions, including rash, urticaria, anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis
RxList

Transient liver enzyme elevation, hepatic dysfunction, and rare renal issues
RxList

Neuromuscular blockade potentiation with anesthetics

Warnings & Precautions
CDAD warning: Monitor for diarrhea; may occur up to several weeks post-therapy

Allergy: Contraindicated in patients with lincomycin/clindamycin hypersensitivity
Medscape Reference

Neuromuscular effects: Use cautiously with neuromuscular blockers

Infants: Use benzyl alcohol–free vials to avoid gasping syndrome

Drug / Class Interaction Potential
Neuromuscular blockers May prolong muscle blockade
Wikipedia
Wikipedia
Warfarin Increased bleeding risk; monitor INR
GoodRx
Antiarrhythmics, seizure meds Monitor as clindamycin levels can be affected
GoodRx
Beclomethasone, acetaminophen May increase clindamycin metabolism
DrugBank

Drug Classification
ATC Code: J01FF01

Pharmacologic Class: Lincosamide antibiotic

Legal Status: Prescription Only (IV/IM form)

Pregnancy Category: A (Australia)

Clinical Evidence
Combination therapy synergy: Clindamycin and gentamicin show synergistic in vitro activity


Effectiveness: Recommended in guidelines for serious anaerobic and Gram-positive infections when penicillin cannot be used

Frequently Asked Questions (FAQs)
Q1: What types of infections does Cleocin Injection treat?
Serious skin, respiratory, bone/joint, intra-abdominal, pelvic, and bloodstream infections caused by susceptible anaerobes and Gram-positive bacteria, including in penicillin-allergic patients
RxList

Q2: How is it dosed?
Adults typically receive 600–1,200 mg/day in divided doses; pediatrics 20–40 mg/kg/day IV/IM
RxList

Q3: What are major risks?
The main risk is CDAD, which can be life-threatening. Allergic reactions and hepatic issues are also possible

Q4: Who should avoid this drug?
Patients with history of colitis, hypersensitivity to lincosamides, or receiving neuromuscular blockers require caution
Medical News Today


Q5: Can it be used with surgery?
Yes. It’s often used prophylactically in penicillin-allergic patients undergoing surgery involving anaerobic flora
RxList
Mayo Clinic

Store at 2–8 °C; protect from light

Use single-dose vials in neonates to avoid benzyl alcohol

Discard unused solution according to hospital policy

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