Coversyl‑AM® (Perindopril + Amlodipine) – Dual Cardiovascular Therapy

Buy Coversyl‑AM Tablets | Perindopril Amlodipine Combination

Coversyl‑AM combines an ACE inhibitor (perindopril) with a calcium‑channel blocker (amlodipine), offering once‑daily blood pressure control. It’s indicated for patients with hypertension and stable coronary artery disease, showing superior reduction in cardiovascular risk compared to monotherapies.

Brand Name: Coversyl‑AM®

Generic Name: Perindopril erbumine + Amlodipine

Form: Film‑coated tablet (e.g., 4 mg/5 mg, 8 mg/5 mg, 10 mg/4 mg, etc.) ([turn0search4], [turn0search13])

Drug Classification: ACE inhibitor + dihydropyridine calcium‑channel blocker

Prescription Status: Rx only

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Perindopril: ACE inhibitor lowering angiotensin II; brand: Coversyl, Prestalia ([turn0search16])

Amlodipine: Dihydropyridine calcium‑channel blocker; brand: Norvasc, Prestalia ([turn0search21])

Fixed‑dose combinations include: Prestalia (Perindopril/Amlodipine) ([turn0search0])

Perindopril blocks ACE, reducing vasoconstriction and aldosterone, promoting vasodilation and natriuresis ([turn0search16])

Amlodipine inhibits calcium influx in vascular smooth muscle, reducing peripheral resistance and afterload ([turn0search21])

Combination provides synergistic blood pressure control and cardioprotection ([turn0search3], [turn0search10])

Essential hypertension, especially when monotherapy is inadequate

Stable coronary artery disease (angina prophylaxis) ([turn0search13], [turn0search14])

Reduction in cardiovascular risk demonstrated versus beta-blocker/diuretic regimens (ASCOT-BPLA trial) ([turn0search3], [turn0search12])

Start with Perindopril 4 mg / Amlodipine 5 mg tablet once daily

Titrate every 1–2 weeks (e.g., increase to 8/5, 10/4) based on response and tolerability ([turn0search6], [turn0search13])

Take at the same time daily, with or without food

Do not split or crush the tablet

Contraindications: Angioedema history, pregnancy, bilateral renal artery stenosis, concurrent aliskiren, sacubitril use ([turn0search6], [turn0search13])

Use with caution in: renal/hepatic impairment, elderly, heart failure, hypovolemia

Monitoring: Regular blood pressure, serum potassium, creatinine in renal disease, edema, liver function tests ([turn0search4])

Edema, headache, dizziness, palpitations, flushing, cough (ACE‑inhibitor cough), fatigue, gastrointestinal upset ([turn0search4], [turn0search6])

Serious:

Angioedema, hyperkalemia, hypotension, renal dysfunction, elevated liver enzymes

Angioedema risk: Discontinue if facial/swallowing swelling occurs

Hypotension risk: Monitor in volume-depleted individuals

Renal impairment: Check kidney function and electrolytes

Pregnancy and breastfeeding: Contraindicated—perindopril has teratogenic effects ([turn0search22])

Aliskiren and sacubitril: Risk of hypotension, hyperkalemia; contraindicated ([turn0search6], [turn0search13])

NSAIDs: May reduce antihypertensive efficacy; monitor renal function

CYP3A4 inhibitors (e.g., itraconazole, ritonavir): Increase amlodipine levels; risk hypotension ([turn0search14])

Other antihypertensives: Additive effects—monitor BP

Potassium supplements/spirolactone: Risk hyperkalemia

Alcohol: May potentiate BP drop

Diuretics, lithium, potassium‑sparing agents: Close monitoring required

ATC Code: C09BB04 (ACE inhibitor + calcium‑channel blocker combo)

Therapeutic Class: Antihypertensive combination

Prescription Status: Rx-only

Clinical Evidence
STRONG study (India): real-world data in 336 clinics showed significant BP control and tolerability using Coversyl‑AM ([turn0search3], [turn0search11])

ASCOT-BPLA trial: demonstrated enhanced cardiovascular outcomes with perindopril + amlodipine vs beta-blocker/diuretic ([turn0search3], [turn0search12])

Frequently Asked Questions (Q&A)
Q1: Why combine two drugs in one pill?
Combining addresses multiple hypertension mechanisms and improves BP control and compliance, reducing CV risk compared to monotherapy or other combos ([turn0search3], [turn0search10]).

Q2: When will it start working?
Amlodipine effect seen within hours, peak after 6–8 weeks; perindopril’s effect in ~1–2 weeks. Full effect seen after dose titration.

Q3: Is Coversyl-AM safe during pregnancy?
No. ACE inhibitors cause fetal harm (oligohydramnios and malformations). Stop if pregnancy detected ([turn0search6], [turn0search22]).

Q4: What if I miss a dose?
Take when remembered unless >12 h until next dose; then skip the missed dose. Do not double dose.

Q5: Can I stop taking it once BP is controlled?
No. Hypertension management requires long-term therapy even when asymptomatic.

Store at below 30 °C in a dry place ([turn0search4])

Keep out of children’s reach

Keep in blister until use

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