Comprehensive Product Description Guide: Generic Coversyl AM (Perindopril + Amlodipine)

Generic Coversyl AM combines Perindopril (an ACE inhibitor) and Amlodipine (a calcium channel blocker) to treat high blood pressure and reduce the risk of cardiovascular events. It helps relax blood vessels and improve blood flow, providing effective 24-hour blood pressure control.

Generic Coversyl AM – Perindopril + Amlodipine Tablets

Perindopril arginine or erbumine (Angiotensin-Converting Enzyme Inhibitor – ACEI)

Amlodipine besylate (Dihydropyridine Calcium Channel Blocker)

Other Popular or Common Names:
Brand Name Equivalent: Coversyl Plus, Coversyl AM, Prexum Plus

Generic Names: Perindopril/Amlodipine

Drug Class: Combination antihypertensive agent

Therapeutic Class: Antihypertensive, Cardiovascular Risk Reduction

Pharmacological Class:

Perindopril: ACE Inhibitor

Amlodipine: Dihydropyridine Calcium Channel Blocker

Australian Schedule: S4 (Prescription Medicine)

This fixed-dose combination offers dual antihypertensive mechanisms:

Perindopril (ACE Inhibitor)

Blocks conversion of angiotensin I to angiotensin II

Reduces vasoconstriction and aldosterone secretion

Decreases blood pressure and cardiac afterload

Improves endothelial function

Amlodipine (Calcium Channel Blocker)

Inhibits calcium influx into vascular smooth muscle

Promotes vasodilation of arteries

Lowers peripheral vascular resistance and blood pressure

Together, they deliver synergistic blood pressure control, reduce proteinuria, and minimize cardiovascular risk, particularly in patients with comorbidities like diabetes, coronary artery disease, or chronic kidney disease.

Essential Hypertension (mild to severe)

High cardiovascular risk with coexisting diabetes, stroke, or heart disease

Patients requiring dual antihypertensive therapy

Stable angina (off-label)

Form: Oral tablet (various strengths available)

Common Dosage Strengths:

5mg Perindopril + 5mg Amlodipine

10mg Perindopril + 5mg Amlodipine

10mg Perindopril + 10mg Amlodipine

Administration:

Take once daily in the morning, with or without food

Swallow whole with water; do not crush or chew

Dose titration may be required under supervision

Initial Dose (if switching from monotherapy):

Based on prior dose of perindopril or amlodipine

Usually 5mg/5mg once daily

Manufacturer: Generic pharmaceutical brands (check local supplier)

Storage: Store below 25°C in a cool, dry place

Prescription Required: Yes

Pack Size: Typically 30 tablets
History of angioedema with ACE inhibitors

Pregnancy and lactation

Bilateral renal artery stenosis

Hypersensitivity to perindopril, amlodipine, or other dihydropyridines

Severe hypotension or shock

Monitor renal function and serum potassium regularly

Avoid abrupt withdrawal, especially in angina patients

Use with caution in patients with hepatic or renal impairment

May cause symptomatic hypotension in volume-depleted patients

Headache

Dizziness

Peripheral edema (amlodipine-related)

Dry cough (perindopril-related)

Fatigue

Nausea

Rash

Muscle cramps

Hypotension

Bradycardia

Palpitations

Serious:
Angioedema (rare but life-threatening)

Severe hypotension

Acute renal impairment

Hepatic dysfunction

Potassium-sparing diuretics (e.g., spironolactone): Risk of hyperkalemia

NSAIDs: May reduce antihypertensive effect and worsen renal function

Lithium: Increased lithium toxicity

Other antihypertensives: Additive effects

Simvastatin: Amlodipine may increase statin exposure

Grapefruit juice: May increase amlodipine levels

ASCOT-BPLA Trial: Demonstrated superior cardiovascular outcomes with perindopril/amlodipine combo vs beta-blocker/thiazide in hypertensive patients.

ADVANCE Study: Perindopril-based therapy significantly reduced microvascular and macrovascular complications in diabetics.

EUROPA Trial: Perindopril reduced major cardiovascular events in patients with stable coronary artery disease.

FAQs – Frequently Asked Questions
Q: What is the benefit of using Generic Coversyl AM over separate tablets?
A: Combining perindopril and amlodipine in one pill improves compliance and offers synergistic blood pressure control with fewer side effects compared to monotherapy.

Q: Can Coversyl AM be used in diabetics or those with kidney disease?
A: Yes. It's often preferred for these patients as it helps reduce proteinuria and preserves renal function, but renal function must be monitored.

Q: How soon will I see results with Generic Coversyl AM?
A: Blood pressure lowering effects may begin within 1–2 days, with full effect typically seen in 1–2 weeks.

Q: What if I miss a dose?
A: Take it as soon as remembered on the same day. Do not double the next dose.

Q: Is this medication safe during pregnancy?
A: No. ACE inhibitors like perindopril can cause injury or death to the developing fetus. Not recommended for use during pregnancy.
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