Cyklokapron® Injection – Emergency Antifibrinolytic for Bleeding Control
Buy Cyklokapron Injection (Tranexamic acid) – Prevent Excessive Bleeding | EZ Chemist Pharmacy

Cyklokapron (tranexamic acid) is an intravenous antifibrinolytic used to prevent or reduce bleeding in surgery, trauma, dental procedures (especially in hemophilia), and postpartum hemorrhage. It works by stabilizing blood clots through lysine receptor blockade, effectively reducing excessive blood loss.

Brand Name: Cyklokapron®

Generic Name: Tranexamic Acid

Drug Class: Antifibrinolytic agent

Formulation: 100 mg/mL injection (10 mL ampoule or vial)

Prescription Status: Rx only

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Tranexamic acid (TXA) – Lysine analog antifibrinolytic
Common brands/generics include Lysteda (oral), Evana, Exacyl, Transamin, and Cyclo‑F 
Mayo Clinic
Tranexamic acid reversibly binds to plasminogen and plasmin, preventing plasmin from degrading fibrin. It stabilizes blood clots and inhibits excessive bleeding 
Prevents bleeding in hemophilia patients undergoing dental extraction 

Off-label in surgery, trauma, postpartum hemorrhage, nosebleeds, and hereditary angioedema 

CRASH-2 & 3 trials support reduced mortality in trauma and postpartum hemorrhage when administered early 
Dental in hemophilia: 10 mg/kg IV before procedure, then 10 mg/kg every 6–8 h for 2–8 days 
Pfizer Medical Information

Trauma/Postpartum/Surgery: Typically 1 g IV over ≥10 min, followed by infusion or repeated dose as required 

Administration tips: Infuse no faster than 1 mL/min; strictly IV to avoid severe complications 
Pfizer Medical Information

Contraindications: Intravascular clotting (e.g., DIC), subarachnoid hemorrhage, and hypersensitivity to tranexamic acid 

Thrombosis risk—avoid with prothrombotic drugs or conditions 
Pfizer Labeling

Seizure risk—especially with neuraxial administration or high dosing; use EEG monitoring if needed 
MPR

Renal impairment—dose reduction is required 
Pfizer Medical Information

Visual disturbances (color vision, retinal changes)—monitor and discontinue if needed 

Common & Serious Side Effects
Common: Nausea, vomiting, diarrhea, dizziness, mild rash 
MPR

Serious: Seizures, thromboembolism (DVT/PE), vision changes, hypotension (if injected too quickly), anaphylaxis 
Mayo Clinic

Always confirm IV route—never administer intrathecally or epidurally; errors can cause seizures or death 
Pfizer Labeling
Avoid in patients with active thrombotic events or high risk (e.g., hormone contraceptive use) 
RxList

Regular renal function and eye exams for long-term use 
Pfizer Labeling
MPR

Monitor for hypersensitivity and visual issues throughout therapy 
Pfizer Medical Information

Prothrombotic agents (e.g., Factor IX complexes, estrogen contraceptives): increased thrombosis risk—avoid concurrent use 
Pfizer Medical Information

Coadministration with anticoagulants or thrombolytics—requires close monitoring and risk assessment 
Pfizer Labeling
RxList

ATC Code: B02AA02

Therapeutic Class: Antifibrinolytic

Prescription Status: Rx only (IV administration)

Clinical Evidence
CRASH-2 trial: 10 mg/kg reduces mortality in trauma when given within 3 hours 
MPR

CRASH-3 trial: Demonstrated reduction in death among traumatic brain injury patients 

Postpartum hemorrhage studies: 1 g early dose reduces maternal death 

Frequently Asked Questions (Q&A)
Q1. Who is Cyklokapron injection for?
It’s used for short‑term prevention or treatment of bleeding in hemophilia, trauma, postpartum hemorrhage, major surgery, hereditary bleeding disorders, and nosebleeds 
RxList

Q2. How fast does it work and how is it given?
It stabilizes clots almost immediately and is administered over at least 10 minutes via IV infusion. Faster injection can cause hypotension 
FDA Access Data

Q3. Is it safe with hormonal contraceptives?
Use caution—combined use raises thrombosis risk; monitor or consider alternate contraception 
FDA Access Data

Q4. Can patients with seizures take it?
Only under specialist supervision with dose adjustment and monitoring, especially in neurological or cardiac procedures 
FDA Access Data
MPR

Q5. What should patients watch for?
Signs of clots (leg swelling, chest pain), sudden vision changes, seizures, or allergic symptoms. Administer slowly and by IV only.
Store below 30 °C, protected from light

Use ampoules single-use only—discard leftover dose after use 
Pfizer Labeling

Label IV syringes clearly “IV ONLY – Tranexamic Acid”

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