Comprehensive Product Description: Generic Cyklokapron Injection (Tranexamic Acid Injection)

Generic Cyklokapron (Tranexamic Acid Injection) is used to treat or prevent excessive bleeding caused by trauma, surgery, heavy menstruation, or medical conditions that affect blood clotting. It works by blocking enzymes that dissolve blood clots.

Generic Cyklokapron Injection
(Tranexamic Acid Injection BP)
Tranexamic Acid
Antifibrinolytic agent

TXA Injection

Tranex Injection

Hemostatic agent

Generic Cyklokapron
Therapeutic Class: Hemostatic / Antifibrinolytic

Pharmacologic Class: Synthetic Lysine Analog

ATC Code: B02AA02

Prescription Schedule: S4 (Prescription-only medication)
Tranexamic Acid is a synthetic derivative of the amino acid lysine. It inhibits fibrinolysis by competitively blocking the lysine-binding sites on plasminogen molecules. This action prevents plasmin (an enzyme that breaks down fibrin clots) from degrading fibrin, thus stabilizing blood clots and reducing bleeding.
Generic Cyklokapron Injection is indicated for the treatment and prevention of:

Heavy menstrual bleeding (menorrhagia)

Post-operative bleeding (especially in cardiac, orthopedic, or dental surgeries)

Traumatic hemorrhage

Bleeding in hemophiliacs during tooth extraction

Gastrointestinal bleeding

Bleeding associated with inherited or acquired coagulation disorders

Obstetric hemorrhage (including postpartum bleeding)

Prophylaxis in surgeries with high bleeding risk
Form: Injectable solution
Strength: Typically available as 100 mg/mL in 5 mL or 10 mL ampoules
General Bleeding: 1 g (10 mL) IV every 6–8 hours

Cardiac Surgery: Loading dose of 10 mg/kg IV followed by infusion

Heavy Menstrual Bleeding (when oral form not feasible): 1 g IV 3 times daily

Trauma/Obstetric Use: 1 g IV over 10 minutes, repeat after 30 minutes to 24 hours depending on bleeding severity
IV (intravenous) slow injection over 10 minutes

Can also be infused over a longer duration when required

Note: Always follow the individualised dosing plan provided by the prescribing physician based on indication, severity, and patient response.
Should be administered in a clinical or hospital setting

Close monitoring required in patients with renal impairment

Not recommended for subcutaneous or intramuscular use
Contraindications:
Hypersensitivity to tranexamic acid

Active thromboembolic disease (e.g., DVT, PE, cerebral thrombosis)

History of seizures (especially at high doses)

Subarachnoid hemorrhage

Precautions:
Use with caution in renal impairment – dose adjustment needed

Monitor for signs of thrombosis

Risk of visual disturbances – regular eye exams recommended for long-term use

Seizure risk in high-dose therapy

Avoid in patients with disseminated intravascular coagulation (DIC) without heparin
Common (1–10%):
Nausea

Vomiting

Diarrhea

Muscle cramps

Injection site pain

Less Common (0.1–1%):
Hypotension (if administered too rapidly)

Headache

Fatigue

Back pain

Rare (<0.1%):
Seizures (dose-dependent)

Thromboembolic events (DVT, stroke, myocardial infarction)

Allergic reactions including rash or anaphylaxis

Visual disturbances (color vision changes)
Tranexamic Acid may interact with:

Hormonal contraceptives: Increased risk of thrombosis

Factor IX or anti-inhibitor coagulant complex: Increased thrombotic risk

Tretinoin or other pro-coagulants: Caution required

Anticoagulants (e.g., warfarin, heparin): May counteract effects—monitor coagulation parameters

Clinical Evidence and Efficacy:
CRASH-2 Trial (2010): Showed significant reduction in death due to bleeding when tranexamic acid was administered early to trauma patients

WOMAN Trial (2017): Demonstrated that TXA significantly reduces postpartum hemorrhage mortality if given within 3 hours

Multiple clinical studies support its efficacy in orthopedic surgery, menorrhagia, and hemophilia-related dental extractions

Frequently Asked Questions (FAQs):
Q: What is Generic Cyklokapron Injection used for?
A: It is used to control or prevent excessive bleeding during surgeries, trauma, or medical conditions like heavy menstruation or hemophilia.

Q: How is Cyklokapron Injection administered?
A: It is administered intravenously, usually in a hospital under medical supervision.

Q: Is it safe during pregnancy?
A: Tranexamic acid can be used in pregnancy, especially in life-threatening postpartum hemorrhage. However, only under medical supervision.

Q: Can it cause blood clots?
A: There's a potential risk, especially in patients with a history of thromboembolic events. Risk-benefit assessment is essential.

Q: Can I use it for heavy periods?
A: Yes, though oral tranexamic acid is more commonly used for that purpose. Injectable form may be used if oral intake is not feasible.
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