GastroStop Loperamide 2 mg – 20 Capsules
Fast-acting antidiarrheal Capsulees for acute and chronic diarrhea relief

Loperamide hydrochloride 2 mg per Capsulee – a synthetic opioid that slows intestinal motility by agonizing μ-opioid receptors in the gut

Other OTC brands: Imodium, Diamode; generic name: loperamide

Class: Antidiarrheal, P‑glycoprotein substrate

Status: OTC pharmacy medicine (schedule depending on packaging size)

Binds μ-opioid receptors in the intestinal wall → decreases peristalsis, prolongs transit time, increases fluid/electrolyte absorption, reduces stool frequency and urgency

Symptomatic treatment of acute non-specific diarrhea

Chronic diarrhea in inflammatory bowel disease or ileostomies

Traveler’s diarrhea relief

Age Group Initial Dose Follow-up Dosing Max/24h Duration
Adults & ≥12 years 4 mg (2 Capsulees) after first loose stool 2 mg (1 Capsulee) after each subsequent loose stool 16 mg OTC (8 caps); 20 mg Rx ≤48 h without medical advice; longer under guidance
8–12 years (≤30 kg) 2 mg 3×/day — 6 mg Consult doctor
6–8 years 2 mg 2×/day — 4 mg Consult doctor
<2 years Not recommended — — —

Swallow with water; may take with or without food

Common: constipation, abdominal pain, dry mouth, nausea, dizziness, fatigue
Serious/Rare: allergic reactions, cardiac arrhythmias (QT prolongation, torsades de pointes) in overdose or drug interactions, paralytic ileus, CNS depression at supratherapeutic doses

Avoid in children <12 years (unless prescribed)

Do not use if diarrhea is accompanied by fever, blood, acute abdominal pain, or lasts >48 hours without medical attention

Use caution in liver disease, heart rhythm disorders

Pregnancy/Breastfeeding: Use only if benefits outweigh risks

Monitor hydration; replace fluids and electrolytes to prevent dehydration

CYP3A4/CYP2C8 inhibitors (e.g., itraconazole, clarithromycin) can raise loperamide levels → risk of cardiac toxicity

P-glycoprotein inhibitors may increase blood-brain barrier penetration → CNS effects

Other interactions: abiraterone, carbamazepine, gemfibrozil — dose adjustment and monitoring advised

Generic: Loperamide hydrochloride 2 mg

Formulation: Oral hard Capsulee

Class: Anti-diarrheal, OTC

Availability: Pharmacy medicine

❓ Frequently Asked Questions
Q1. How quickly does GastroStop work?
A1. Relief typically begins within 1–3 hours after the first dose, due to slowed intestinal motility

Q2. Can I take it with food?
A2. Yes — take with or without food, but ensure adequate hydration.

Q3. What if symptoms persist or worsen?
A3. Stop after 48 hours; if diarrhea continues, is bloody, or is accompanied by fever or severe abdominal pain, seek medical advice

Q4. Is it safe in children?
A4. Use only in children aged ≥6 years—with doses adjusted by weight and under medical supervision. Avoid use in <2 years .

Q5. What about overdose or excessive use?
A5. Overdose risks include serious cardiac events and CNS depression. In emergencies, administer naloxone for opioid effects and manage arrhythmias .

What is GastroStop (Loperamide) used for?
GastroStop delivers 2 mg of loperamide per Capsulee to slow bowel movements and reduce diarrhea symptoms in adults and children (≥6 years). The standard dose is 4 mg initially, followed by 2 mg after each loose stool (max 8 Capsulees/day OTC) for up to 48 hours. Discontinue and consult a doctor if diarrhea persists or is accompanied by fever or blood.

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