Coversyl (Perindopril Erbumine) – Complete Product Guide for EZ Chemist Online Pharmacy

Coversyl, containing the active ingredient Perindopril, is an ACE inhibitor prescribed to treat high blood pressure (hypertension), heart failure, and to reduce the risk of cardiac events in patients with stable coronary artery disease. It works by relaxing blood vessels, making it easier for the heart to pump blood efficiently. Coversyl is typically used as a long-term therapy and may be used alone or in combination with other medications.

Coversyl (Perindopril Erbumine)

Common strengths include: 2 mg, 4 mg, 8 mg tablets
(Also available in combination with Indapamide as Coversyl Plus or Coversyl Plus HD)

Perindopril Erbumine (also known as Perindopril Tert-butylamine)

Other Common Names and Brand Equivalents:
Generic Name: Perindopril

Brand Names: Coversyl, Aceon, Prestarium, Coversum

Class: Angiotensin-Converting Enzyme (ACE) Inhibitor

Coversyl belongs to the ACE inhibitor class of medications. It acts by inhibiting the angiotensin-converting enzyme (ACE) which is responsible for converting angiotensin I to angiotensin II – a potent vasoconstrictor. By blocking this conversion:

It relaxes blood vessels, reducing blood pressure

Improves blood flow to the heart and kidneys

Reduces the cardiac workload and prevents progression of heart failure

Lowers the risk of recurrent cardiovascular events such as heart attacks or strokes

Essential Hypertension (High Blood Pressure)

Chronic Heart Failure

Stable Coronary Artery Disease (to reduce the risk of cardiac events)

Post-Myocardial Infarction Left Ventricular Dysfunction

Diabetic Nephropathy (kidney protection in diabetic patients)

Microalbuminuria in hypertension or diabetes

Vascular protection in elderly patients

Condition Typical Starting Dose Maintenance Dose Maximum Dose
Hypertension 4 mg once daily 4–8 mg once daily 8 mg once daily
Heart Failure 2 mg once daily 4 mg once daily 4 mg once daily
Stable CAD 4 mg once daily (2 weeks) Increase to 8 mg/day 8 mg once daily

Should be taken once daily, preferably in the morning before food

Dosage must be titrated based on renal function, age, and clinical response

Elderly: Initiate at 2 mg/day with caution
Renal Impairment: Adjust dosing based on creatinine clearance
Not recommended in children or during pregnancy

Prescription Required: Yes

Dosage Form: Oral tablet

Onset of Action: 4–6 hours

Half-life: Approximately 3–10 hours (active metabolite perindoprilat)

Elimination: Primarily renal

Possible Side Effects of Coversyl (Perindopril):
Common Side Effects:
Dry, persistent cough

Dizziness, fatigue

Nausea, abdominal pain

Headache

Taste disturbances

Angioedema (swelling of lips, face, throat – medical emergency)

Severe hypotension

Renal impairment

Hyperkalemia (high potassium levels)

Hepatotoxicity (rare)

Pregnancy Category D: Contraindicated in pregnancy, especially in 2nd and 3rd trimesters – may cause fetal harm

Lactation: Avoid unless benefits clearly outweigh risks

Kidney Disease: Adjust dose; monitor serum creatinine and potassium

Risk of Hyperkalemia: Especially with potassium-sparing diuretics, supplements

Surgery/Anesthesia: Risk of hypotension under general anesthesia

Discontinue immediately if angioedema occurs

Drug/Class Interaction Effect
NSAIDs (e.g., ibuprofen) Reduced antihypertensive effect; risk of kidney damage
Diuretics (esp. potassium-sparing) Increased risk of hypotension, hyperkalemia
Potassium supplements Risk of dangerously high potassium
Lithium Increased lithium toxicity
Other antihypertensives Additive hypotensive effect

The EUROPA Trial demonstrated a significant reduction in cardiovascular events in patients with stable coronary artery disease on Perindopril.

ACE inhibitors like Coversyl have been shown in meta-analyses (BMJ, 2013) to reduce overall mortality in heart failure and high-risk hypertensive patients.

Therapeutic Class: Antihypertensive

Pharmacologic Class: ACE Inhibitor

ATC Code: C09AA04

Store below 25°C

Keep in original blister pack to protect from moisture and light

Keep out of reach of children

Frequently Asked Questions (FAQ)
Q: Can Coversyl be taken at night?
A: It is typically taken in the morning, but may be used at night if advised by your doctor. Always take it at the same time each day for consistency.

Q: Why does Coversyl cause coughing?
A: Dry cough is a known class effect of ACE inhibitors due to the accumulation of bradykinin. It is usually not harmful but can be persistent.

Q: How long does Coversyl take to lower blood pressure?
A: Noticeable reductions in blood pressure usually begin within 4–6 hours, but full therapeutic effects may take 2–4 weeks of regular use.

Q: Can Coversyl be taken with food?
A: It is best taken before meals, preferably in the morning, as food may reduce its absorption slightly.

Q: Is Coversyl safe during pregnancy?
A: No. Coversyl is contraindicated during pregnancy due to risks of fetal injury or death. Women of childbearing potential should use effective contraception while on this medication.
Buy Coversyl Tablets Online India

Perindopril 4 mg Blood Pressure Medicine

ACE Inhibitor for Heart Failure Treatment

Coversyl 8 mg for Hypertension Control

Prescription Antihypertensive Medicine Online

Order Perindopril Tablets with Fast Delivery

Coversyl Side Effects and Dosage Guide

Best Heart and BP Medicine EZ Chemist

Coversyl for Stable Coronary Artery Disease

Compare Coversyl vs Enalapril Effectiveness