Generic Cordarone Injection (Amiodarone Hydrochloride for Injection)
Compared with: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules

Generic Cordarone Injection (Amiodarone HCl 150 mg/3 mL) is a class III antiarrhythmic indicated for life‑threatening ventricular fibrillation and unstable ventricular tachycardia. A 300 mg IV bolus over 10 minutes followed by a continuous infusion (1 mg/min × 6 h then 0.5 mg/min × 18 h) rapidly stabilizes refractory arrhythmias, with broad ion‑channel blockade and adrenergic inhibition
Mayo Clinic

Amiodarone Hydrochloride – 150 mg per 3 mL ampoule (50 mg/mL)

Pacerone® Injection (US)

Amiodarone IV/IM

Class III Antiarrhythmic

Cordarone IV Solution

Amiodarone’s antiarrhythmic effects derive from:

Potassium‑Channel Blockade (Class III): Prolongs action‑potential duration and refractory period by inhibiting delayed rectifier K⁺ currents.

Sodium‑ and Calcium‑Channel Blockade (Classes I & IV): Reduces conduction velocity and automaticity.

Noncompetitive α‑ and β‑Adrenergic Inhibition: Attenuates sympathetic tone, decreasing AV‑node conduction and heart rate

Pulseless Ventricular Fibrillation & Unstable Ventricular Tachycardia: As per advanced cardiac life‑support algorithms
RxList

Hemodynamically Unstable VT: Acute management in intensive‑care settings.

Off‑Label: Rapid rate control in atrial fibrillation/flutter; adjunct to electrical cardioversion.

Adult IV Regimen
Mayo Clinic
nhs.uk
Initial Bolus: 300 mg IV push over 10 minutes (15 mg/min).

Supplemental: 150 mg over 5 minutes if arrhythmia persists.

Loading Infusion: 1 mg/min for 6 hours (360 mg total).

Maintenance Infusion: 0.5 mg/min for 18 hours (540 mg total).

Maximum 24‑h Dose: 2.2 g to minimize hypotension.

Pediatric (Off‑Label ACLS): 5 mg/kg IV/IO push; may repeat up to 2 times; infusion at 5 µg/kg/min thereafter

Administration Tips: Bolus may be undiluted or in ≥50 mL D₅W; use non‑PVC tubing for infusions >2 mg/mL.

Formulation: Sterile, preservative‑free solution, 50 mg/mL.

Presentation: 150 mg/3 mL single‑dose ampoules.

Route: IV (preferred) or IM injection.

Storage: 20–25 °C; protect from light; use immediately after opening.

Pregnancy: Category D – fetal thyroid, pulmonary, neurologic risks; use only if maternal benefits outweigh risks.

Breastfeeding: Excreted in breast milk; monitor neonate for thyroid and liver effects.

Pediatric: ≥2 years under specialist guidance; weight‑based dosing.

Elderly: Increased risk of hypotension/bradycardia; initiate at lower rates.

Renal/Hepatic Impairment: No formal adjustments; monitor for accumulation due to long half‑life (50–60 days).

Hypotension (10 %)
WebMD

Bradycardia, heart block

Phlebitis at infusion site

Serious:

QT Prolongation → Torsades de Pointes (rare)

Pulmonary Toxicity: Fibrosis with chronic use

Thyroid Dysfunction: Hypo‑ or hyperthyroidism

Hepatotoxicity, Neurologic Effects: In long‑term therapy

Continuous Monitoring: ECG and blood pressure during infusion.

Rebound Arrhythmias: Taper infusion to avoid recurrence.

Pulmonary & Thyroid Surveillance: For prolonged IV/oral therapy.

Liver Injury: Baseline and periodic LFTs.

Agent Effect Recommendation
Warfarin ↑INR via CYP2C9/3A4 inhibition Reduce warfarin dose; monitor INR
Digoxin ↑Digoxin levels via P‑gp inhibition Reduce digoxin dose; monitor levels
Statins (simvastatin/lovastatin) ↑Myopathy risk via CYP3A4 inhibition Use lower statin dose; monitor for toxicity
Beta‑Blockers/CCBs Additive bradycardia, AV block Adjust doses; monitor ECG
Class I Antiarrhythmics ↑Arrhythmia risk with disopyramide, flecainide, etc. Avoid co‑administration

FAQs – Generic Cordarone Injection
Q1. How soon does amiodarone act?
A: Onset within minutes after bolus; maximal effect during loading infusion phase
nhs.uk
Q2. Can bolus be repeated?
A: Yes—150 mg may be repeated after ≥5 minutes for refractory VF/VT (total ≤2.2 g/24 h).

Q3. What monitoring is required?
A: Continuous ECG, invasive or noninvasive BP, and pulse oximetry during and post‑infusion.

Q4. How to manage hypotension?
A: Slow or pause infusion; support with IV fluids or vasopressors.

Q5. Is IM route acceptable?
A: Possible but painful with erratic absorption; IV infusion preferred.

Q6. How transition to oral?
A: Start 200 mg TID oral once stable; overlap oral + IV for ≥24 h.

Q7. How store ampoules?
A: Room temperature 20–25 °C; protect from light; discard if compromised.
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