Pulmopres (Sildenafil) Tablet – Treatment for Pulmonary Arterial Hypertension (PAH)

What is Pulmopres used for
Pulmopres is a prescription medication containing sildenafil citrate, primarily used to treat pulmonary arterial hypertension (PAH). It improves exercise capacity and delays disease progression by relaxing blood vessels in the lungs, enhancing blood flow and reducing pressure.

Brand Name: Pulmopres

Generic Name: Sildenafil Citrate

Strengths Available: 12.5 mg, 25 mg, 50 mg, 100 mg

Drug Class: Phosphodiesterase Type 5 (PDE5) Inhibitor

Form: Oral Tablet

Route: Oral

Manufacturer: Cipla Ltd.

Prescription Required: Yes

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Sildenafil Citrate – A PDE5 inhibitor that improves blood flow by relaxing pulmonary vasculature smooth muscle.

Revatio (US brand for PAH)

Generic Sildenafil for PAH

Pulmonary Hypertension Treatment

PDE5 Inhibitor for PAH

Sildenafil Tablets

Sildenafil in Pulmopres works by selectively inhibiting phosphodiesterase type 5 (PDE5) in the pulmonary vascular endothelium.

PAH is characterized by elevated blood pressure in the pulmonary arteries.

Sildenafil prevents degradation of cGMP, a vasodilator messenger.

Increased cGMP causes vasodilation of pulmonary arteries, reducing pulmonary arterial pressure.

Improves oxygen delivery and exercise capacity.

Onset of Action: Within 30–60 minutes
Duration of Action: Approximately 4–6 hours

Pulmopres is prescribed for:

Pulmonary Arterial Hypertension (PAH) (WHO Group 1)

Improvement in exercise tolerance in PAH patients

Off-label Uses: May include high altitude pulmonary edema (HAPE) prevention (under supervision)

Strength Recommended Dosage Frequency
20–25 mg Three times daily 6–8 hour intervals

Should be taken with or without food.

Must be taken regularly for optimal benefits.

Do not crush or split tablets unless advised by a physician.

Always follow your doctor’s guidance.

Adult dosage should be determined by PAH severity.

Not for use in children under 1 year unless specifically advised.

Use caution in patients with systemic hypotension or concurrent nitrate use.

Periodic blood pressure and pulmonary function monitoring recommended.

Not recommended in severe hypotension (BP <90/50 mmHg)

Contraindicated with nitrate medications

Caution in patients with renal or hepatic impairment

Can interact with other blood pressure-lowering medications

Headache

Flushing

Dyspepsia (indigestion)

Nasal congestion

Visual disturbances (e.g., bluish vision)

Less Common / Serious Adverse Effects:
Hypotension

Hearing loss

Vision loss (non-arteritic anterior ischemic optic neuropathy – NAION)

Priapism (rare)

Seek immediate medical attention if any serious side effect occurs.
Cardiac Conditions: Use with caution in patients with left ventricular outflow obstruction or unstable angina

Hepatic/Renal Impairment: Dosage adjustment may be required

Nitrates: Absolute contraindication due to risk of life-threatening hypotension

Alcohol Use: May exacerbate vasodilation and dizziness

Pregnancy & Lactation: Use only if clearly needed under medical advice

Interacting Drug Class Effect / Risk
Nitrates (e.g., GTN, ISDN) Severe hypotension – contraindicated
Alpha-blockers Enhanced blood pressure drop
CYP3A4 inhibitors (e.g., Ritonavir, Ketoconazole) Increased sildenafil concentration
Antihypertensives Additive BP-lowering effect
Grapefruit Juice Avoid – affects drug metabolism

ATC Code: G04BE03

Schedule: Schedule H (India)

Category: Prescription Only Medication

Regulatory Status: Approved by US FDA, EMA for PAH as Revatio (sildenafil citrate)

Galie N. et al., NEJM, 2005 – Demonstrated significant improvement in 6-minute walk distance and WHO functional class in patients with PAH treated with sildenafil.

Rubin LJ et al., 2002 – Found sildenafil to delay clinical worsening and improve hemodynamics in PAH patients.

FDA Approval for Revatio based on multiple RCTs (randomized controlled trials).

Frequently Asked Questions (FAQs)
Q1. What is Pulmopres used to treat?
Pulmopres is used to treat pulmonary arterial hypertension (PAH) by improving blood flow in the lungs and reducing pulmonary blood pressure.

Q2. Is Pulmopres the same as Viagra?
Both contain sildenafil, but Pulmopres is used for PAH, while Viagra is used for erectile dysfunction.

Q3. Can Pulmopres be taken daily?
Yes, Pulmopres is usually taken three times daily for PAH. Do not exceed prescribed dosage.

Q4. Can I use Pulmopres for erectile dysfunction?
Pulmopres is not indicated for ED. Sildenafil in different dosages (like 50 mg or 100 mg) may be used for ED under brand names like Viagra.

Q5. What precautions should I take while using Pulmopres?
Avoid nitrates, monitor blood pressure, and inform your doctor if you experience chest pain, vision changes, or prolonged erection.

Q6. Is Pulmopres safe in pregnancy?
Sildenafil should only be used in pregnancy if the potential benefit justifies the potential risk, under medical supervision.

Store below 30°C

Keep in a cool, dry place away from direct sunlight

Keep out of reach of children

Do not use expired medication

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