Tadaflo® (Tadalafil) by Cipla
Compared with: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules

Tadaflo (Tadalafil) 2.5 mg, 5 mg, 10 mg, 20 mg tablets by Cipla is a long‑acting phosphodiesterase 5 inhibitor indicated for erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). It enhances nitric‑oxide–mediated vasodilation, offering up to 36 hours of efficacy with once‑daily or as‑needed dosing
1mg
Ciplamed

Tadalafil – available in film‑coated tablets of 2.5 mg, 5 mg, 10 mg, and 20 mg
Ciplamed

Cialis® (brand)

Adcirca® (PAH formulation)

PDE5 inhibitor

“Weekend pill” (reflecting extended duration)

Tadalafil selectively inhibits phosphodiesterase type 5 (PDE5) in vascular smooth muscle, preventing cGMP breakdown. Elevated cGMP enhances nitric‑oxide–mediated relaxation of smooth muscle in:

Corpus Cavernosum – Facilitates erection during sexual stimulation.

Prostatic & Bladder Vessels – Relieves LUTS in BPH by smooth‑muscle relaxation.

Pulmonary Vasculature – Lowers pulmonary vascular resistance in PAH
PharmEasy

Erectile Dysfunction (ED): On‑demand or once‑daily dosing.

Benign Prostatic Hyperplasia (BPH): Once‑daily regimen improves LUTS.

Pulmonary Arterial Hypertension (PAH): High‑dose daily under specialist care.

Indication Initial Dose Frequency & Max Dose Notes
ED (As‑Needed) 10 mg Once prior to activity; max 10 mg per 72 h
Ciplamed
Adjust 5–20 mg based on response
ED (Once Daily) 2.5 mg Once daily; may increase to 5 mg based on efficacy
Practo
Taken same time daily, irrespective of sexual activity
BPH / ED + BPH 5 mg Once daily; max 5 mg Improves LUTS and erectile function
PAH (Adcirca®) 40 mg (2 × 20 mg) Once daily Take at same time each day; specialist supervision
PharmEasy
Renal Impairment (ED) CrCl 30–50 mL/min: 5 mg; <30 mL/min: 5 mg every 72 h — Avoid accumulation
Ciplamed
Hepatic Impairment (ED) Child‑Pugh A/B: max 10 mg; C: contraindicated — Contraindicated in severe disease
Practo

Administration: Swallow tablet with water; can be taken with or without food
Netmeds

Missed Dose: For once‑daily regimens, take when remembered and resume schedule; do not double.

Formulation: Film‑coated oral tablets

Strengths: 2.5 mg, 5 mg, 10 mg, 20 mg

Route: Oral

Legal Status: Prescription Only Medicine

Pregnancy & Breastfeeding: Avoid use unless benefit justifies potential risk; minimal data.

Pediatric: Not established for <18 years.

Elderly: No routine adjustment; monitor hypotension risk.

Renal/Hepatic Impairment: See dosage adjustments.

Common:

Headache, dyspepsia, back pain, myalgia
Ciplamed
1mg

Flushing, nasal congestion

Serious (Rare):

Priapism (erection > 4 hours) – seek immediate care

Sudden vision loss (NAION); sudden hearing decrease – discontinue and evaluate

Hypotension, syncope in predisposed patients

Nitrates: Contraindicated—risk of severe hypotension

Alpha‑Blockers / Antihypertensives: Additive BP lowering—initiate tadalafil at lowest dose and monitor

Cardiovascular Status: Assess if patient can tolerate sexual activity

Priapism: Seek urgent care for erections > 4 hours

Vision/Hearing Loss: Discontinue if sudden changes occur

Therapeutic Class: Erectile Dysfunction Agent; PAH Agent

Pharmacologic Class: Phosphodiesterase 5 Inhibitor

Legal Category: Prescription Only

Class Interaction Effect Recommendation
Nitrates Severe hypotension Absolute contraindication
Alpha‑Blockers Additive hypotension Start tadalafil at 2.5 mg; monitor BP
CYP3A4 Inhibitors (e.g., ketoconazole) ↑Tadalafil levels; ↑risk of side effects ED as‑needed: max 10 mg/72 h; daily: max 2.5 mg
Practo
CYP3A4 Inducers (e.g., rifampin) ↓Tadalafil efficacy Avoid concomitant use
Antihypertensives Additive hypotension Monitor hemodynamics

ED: RCTs show significant improvement in IIEF‑EF scores with tadalafil vs placebo, with effects lasting up to 36 hours (P < 0.001)
Ciplamed

PAH: 40 mg daily improved 6‑minute walk distance by ~33 m at 12 weeks versus placebo (P = 0.02)
PharmEasy

BPH: Tadalafil 5 mg improves IPSS and peak urinary flow when compared to placebo (P < 0.05)
1mg
.

FAQs – Tadaflo (Tadalafil)
Q1. How long before sexual activity should I take Tadaflo?
A: Take 10 mg at least 30 minutes before; efficacy lasts up to 36 hours

Q2. Can I use Tadaflo daily
A: Yes—2.5–5 mg once daily is approved for ED + BPH.

Q3. What if I miss my daily dose?
A: Take as soon as remembered; resume next day at usual time; do not double.

Q4. Is alcohol allowed?
A: Moderate use is acceptable; avoid excessive intake to reduce risk of hypotension.

Q5. What if I get an erection lasting > 4 hours?
A: Seek immediate medical attention to prevent permanent tissue damage.

Q6. Can Tadaflo be combined with other PDE5 inhibitors?
A: No. Avoid combining with sildenafil, vardenafil, etc.

Q7. How should I store Tadaflo?
A: Store at 15–30 °C, away from moisture and heat.

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