Tazzle (Tadalafil) – Prescription Erectile Dysfunction Treatment
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What is Tazzle used for
Tazzle is a prescription medication containing tadalafil, used to treat erectile dysfunction (ED) in men by improving blood flow to the penis during sexual stimulation. It helps achieve and maintain a firm erection.
Brand Name: Tazzle

Generic Name: Tadalafil

Drug Class: Phosphodiesterase Type 5 (PDE5) Inhibitor

Available Strengths: 10 mg, 20 mg

Form: Oral Tablets

Route of Administration: Oral

Prescription Required: Yes

Marketed By: Dr. Reddy’s Laboratories or other Indian pharmaceutical manufacturers

Generic Alternatives: Available as Tadalafil generic

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Tadalafil – A long-acting PDE5 inhibitor that enhances erectile function by increasing blood flow to the penis during sexual stimulation.

Each Tazzle tablet contains Tadalafil as the active pharmaceutical ingredient in strengths of 10 mg or 20 mg.

Generic Cialis

Weekend Pill

Tadalafil Tablets

ED treatment pill

Tazzle 10 / Tazzle 20

Tazzle (Tadalafil) inhibits the enzyme phosphodiesterase type 5 (PDE5), which is responsible for breaking down cyclic guanosine monophosphate (cGMP) in the corpus cavernosum.

Sexual stimulation releases nitric oxide (NO) in the penis.

NO increases cGMP, relaxing smooth muscles and increasing blood flow.

Tadalafil sustains cGMP levels, supporting longer, firmer erections.

Tadalafil has a long half-life of up to 36 hours, earning it the nickname "weekend pill."
Tazzle is used for:

Erectile Dysfunction (ED) in adult men

Benign Prostatic Hyperplasia (BPH) symptoms (in some cases)

Pulmonary Arterial Hypertension (under different brand names)
For Erectile Dysfunction:

Type of Use Recommended Dosage
On-demand 10 mg or 20 mg, 30–60 min before intercourse
Daily use (not standard for Tazzle) 2.5–5 mg once daily at the same time

Do not exceed one dose per day.

Sexual stimulation is required for the drug to work.

Effect may last up to 36 hours.

Administration Tips:

Can be taken with or without food.

Avoid high-fat meals, which may delay onset.

Start with 10 mg for most patients.

Adjust based on efficacy and tolerability.

Not recommended in men under 18 years.

Avoid in combination with nitrate medications.
Pregnancy/Lactation: Not applicable; intended for use in males only.

Renal impairment: Dose adjustment may be necessary.

Hepatic impairment: Use with caution in mild/moderate cases; avoid in severe cases.

Geriatric use: Generally well-tolerated, monitor for comorbidities.
Common Less Common / Serious
Headache Priapism (prolonged erection)
Dyspepsia (indigestion) Sudden hearing or vision loss
Back pain Hypotension (especially with nitrates)
Nasal congestion Cardiovascular events (rare)
Myalgia (muscle aches) Allergic reactions (rash, swelling)

Cardiac Risk: Not recommended in patients advised against sexual activity due to cardiovascular risk.

Nitrate Interaction: Absolute contraindication with nitrates (e.g., nitroglycerin).

Priapism Warning: Seek immediate help if erection lasts more than 4 hours.

Vision/Hearing Loss: Discontinue if sudden loss occurs.

Alcohol Use: May increase risk of hypotension and dizziness.
Interacting Agent Effect
Nitrates (e.g., GTN) Severe hypotension – contraindicated
Alpha-blockers Additive blood pressure lowering
Antihypertensives May increase hypotensive effects
CYP3A4 inhibitors (ketoconazole, ritonavir) Increase Tadalafil levels
Grapefruit Juice May increase bioavailability – avoid

Tadalafil is primarily metabolized by the CYP3A4 enzyme in the liver.
ATC Code: G04BE08

Schedule: Prescription Only Medicine (POM)

Therapeutic Class: Erectile Dysfunction Treatment

Legal Classification: Not a controlled substance

Clinical Studies & Efficacy
Porst H. et al. (2001, J Urol):
Tadalafil significantly improved erectile function compared to placebo in multiple international trials.

Coady DJ et al. (2006):
Long-term use of tadalafil showed consistent improvements in ED with minimal side effects.

FDA and EMA Approved:
Tadalafil is approved globally for treatment of ED and BPH.

Frequently Asked Questions (FAQs)
Q1. What is Tazzle used for?
Tazzle is prescribed to treat erectile dysfunction (ED) by improving blood flow to the penis.

Q2. How long does Tazzle last?
Tazzle can remain effective for up to 36 hours, allowing more spontaneity.

Q3. Can I take Tazzle with alcohol?
Moderate alcohol is generally safe, but excessive intake may reduce the drug's effectiveness and cause dizziness.

Q4. Is Tazzle safe for daily use?
Tazzle is designed for on-demand use. For daily dosing, only low-dose tadalafil (2.5–5 mg) is approved.

Q5. What if I miss a dose?
If taking it as needed, missing a dose means you can simply take it before your next intended sexual activity.

Q6. Is Tazzle the same as Cialis?
Yes, Tazzle contains the same active ingredient (Tadalafil) as Cialis, but may differ in branding and price.
Store in a cool, dry place below 25°C

Keep out of reach of children

Protect from moisture and sunlight

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